Közvetlenül a 4 Metró F kijáratánál
34 Results from this investigation might provide you are able to factors getting inconsistent results in earlier in the day degree researching the result away from calcium toward colorectal carcinogenesis. 6,8,9,ten,35,36 An earlier data hypothesised the chemotherapy-precautionary aftereffects of calcium supplements intake towards the CRC can get generally use its outcomes only in the beginning (i.age., adenoma). sixteen All of our findings was consistent with early in the day epidemiologic data, fifteen,37 recommending large calcium intake might only inhibit very early colorectal carcinogenesis from the phase out-of experience adenoma 6,seven,8,9,ten,fifteen additionally the relationship tends to be stronger to have reduction away from experience advanced adenoma, good premalignant lesion to possess CRC, fifteen than many other variety of adenoma/polyps. 38 The choice are consistent with the observation the magnitude out of lack of full CRC chance on the highest calcium supplements consumption is a lot like the brand new loss of adenoma chance.
Within analysis, i did not to see people important connectivity otherwise manner between calcium consumption and you may metachronous adenomas. not, of your own three consequences i examined, decide to try proportions and mathematical energy have been as well as the smallest for it data. thirteen Indeed, brand new demo located supplementation from calcium alone otherwise calcium also supplement D substantially enhanced danger of sessile serrated adenomas or polyps during the the brand new prolonged realize-upwards. fourteen Almost every other hidden facts get account fully for the brand new inconsistency ranging from these types of randomised products, such separating sessile serrated adenomas otherwise polyps regarding adenoma or polyps in addition to improvement in the latest California:Milligrams consumption ratios along the time. The fresh California:Milligrams consumption ratio on the research populations has increased out-of
For this reason, our efficiency suggest that the perfect California:Mg proportion can be receive somewhere within step one
dos.six from inside the earlier examples to help you >3.0 recently. 11,twelve,39 A key goal of this study were to read the whether or not a maximum Ca:Milligrams ratio enhances the protective connections between calcium supplements and you will colorectal outcomes. Working for the restrictions of one’s analysis lay if you find yourself adding degree out of past studies, we put new California:Mg ratio slashed-factors at the step 1.eight, the lower sure of Ca:Milligrams ratio, below and this calcium supplements consumption has not yet seen to be of use, 18 and you may dos.5, the brand new median, that can approximates top of the sure of your of good use Ca:Mg proportion suggested for the previous education from the 2.six. 17
It is possible that 2.5 may not serve as the optimal Ca:Mg ratio cut point to differentiate adequate vs. inadequate Ca:Mg ratios. It is also notable that the magnitudes of the inverse associations between calcium and distal CRC are weaker in the >2.5 Ca:Mg ratio category than compared with the middle category (1.7–2.5). The Ca:Mg ratio strata of <1.7 had too few observations to make explicit extrapolations. Nonetheless, the waning of the observed inverse association between calcium and distal CRC with increasing Ca:Mg ratio categories is also reflected in the positive beta estimate for the interaction term when calcium and Ca:Mg ratio were modelled as continuous variables (data not shown). 7 and 2.5.
No matter if prior to randomised samples located calcium supplements supplementation shorter chance of colorectal metachronous adenoma, eleven a current trial regarding calcium supplements supplements didn’t get a hold of particularly a connection
In an earlier study, we reported that the dietary intake ratio of Ca:Mg modified the association between calcium, magnesium and prevalent colorectal adenoma. 6 In a subsequent randomised clinical trial, calcium supplementation only recensione app incontri poliamorosi reduced risk of metachronous colorectal adenoma when the baseline Ca:Mg ratio was <2.63. 17 We found that the Ca:Mg ratio modified the associations between intakes of calcium and magnesium and risk of oesophageal neoplasia. 18 A case–control study conducted in Belgium reported that a high calcium intake with a low magnesium intake was associated with increased risk of bladder cancer. 40 In studies conducted in East Asian populations with a low Ca:Mg intake ratio (a median around 1.7), the association between intakes of calcium and magnesium and several outcomes (total, cardiovascular and/or cancer mortalities) were modified by the Ca:Mg ratio, but not by calcium or magnesium intake alone. 19 In a randomised trial, we found reducing Ca:Mg ratios to around 2.3 through magnesium supplementation optimised vitamin D status (i.e., increasing blood 25-hydroxyvitamin D3 (25(OH)D3) when baseline 25(OH)D levels were lower, but decreasing 25(OH)D3 when baseline 25(OH)D were higher). 20,21 Thus, the optimal balance between calcium and magnesium intake is a critical factor to consider in the investigation of associations between intakes of calcium and magnesium and cancer development.
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