Cyclobenzaprine Flexeril Misuse, & Addiction Treatment

Using cyclobenzaprine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. In the higher dose groups this microscopic change was seen after 26 weeks and even earlier in rats which died prior to 26 weeks; at lower doses, the change was not seen until after 26 weeks. The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment).

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Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly). There are other drugs available to treat your condition. Talk with your doctor about other drug options that may work for you.

If they’re more severe or don’t go away, talk with your doctor or pharmacist. Abuse of cyclobenzaprine is relatively rare but most often occurs in the context of other substance use. Polydrug abuse can cause serious harm, especially when the combination includes CNS depressing substances such as benzodiazepines and alcohol.

Side effects

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use cyclobenzaprine only for the indication prescribed. You are encouraged to report negative side effects of prescription drugs to the FDA. All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. Using Flexeril with other drugs that make you drowsy can worsen this effect.

• Although Flexeril doesn’t produce a euphoric high like many other drugs, people still misuse it due to its relaxing effects; many will increase dosages to amplify those effects.
• Analysis of the data from controlled studies shows that FLEXERIL produces clinical improvement whether or not sedation occurs.
• Contact your care team if the problem does not go away or is severe.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems.
• You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.

If you notice other effects not listed above, contact your doctor or pharmacist. Cyclobenzaprine HCl relieves skeletal muscle spasm of local origin without interfering with muscle function. It is ineffective in muscle spasm due to central nervous system disease. It is not known whether this drug is excreted in human milk. Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when FLEXERIL is administered to a nursing woman.

Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Animal studies don’t always predict the way humans would respond. Therefore, this drug should only be used in pregnancy if clearly needed. Many insurance companies require prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Drug Interactions

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. It isn’t known exactly how this drug works to relax your muscles. It may decrease the signals from your brain that tell your muscles to spasm.

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If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. It works by blocking pain sensations that are sent to your brain.

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The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication can you take flexeril and motrin together helpfulness, and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome). Yes, cyclobenzaprine can make you very sleepy and this side effect may get worse with higher doses. Drowsiness is the most commonly reported side effect in studies, occurring in up to 38% (38 out of 100) of people.

The risk of overdose is significantly increased when Flexeril is combined with other drugs, particularly alcohol or Benzodiazepines. This combination can cause extreme drowsiness and respiratory depression, but many people that abuse Flexeril will mix the substances anyway simply to increase the intoxication experienced. Yes, you can overdose on Flexeril — including cyclobenzaprine 10 mg dose.

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